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Multiple Myelomas

Overview

What is the Myelomas?

B lymphocytes (B cells), a type of white blood cell generated in the bone marrow, give rise to plasma cells. When bacteria or viruses infect the body, the B cells transform into plasma cells. These plasma cells start synthesising antibodies, which fight bacteria and viruses and prevent infection and illness.

What is Multiple Myelomas?

Multiple myeloma or Kahler’s disease occurs when the plasma cells become cancerous, start dividing abnormally in the bone marrow and eventually form tumours in various bones present in the body.

Causes

The exact cause of multiple myeloma is unknown. However, a few risk factors for multiple myeloma have been identified:
History of Monoclonal Gammopathy of Undetermined Significance (MGUS): In most cases, multiple myeloma starts as MGUS, which is a benign condition wherein an abnormal protein called the M protein is present in the blood.
Age: The risk of getting multiple myeloma increases with age.
Gender: Multiple myeloma is found to be more common in men than women.
Obesity: Studies have found that those with obesity are at a higher risk of developing multiple myeloma.
Ethnicity: This condition is found to be more prevalent among people of African and African-American ethnicity.

Diagnosis

Multiple diagnostic methods are available to detect and diagnose multiple myeloma. Our specialists at HCG provide superior diagnostic support to patients with multiple myeloma and ensure that they receive the right treatment, the first time.

a. Physical Examination and Medical History Assessment

b. Lab Tests

c. Bone Marrow Biopsy

d. Imaging Tests

Treatment

There are various treatment options available for multiple myeloma. Timely diagnosis and appropriate treatment plans support the successful management of multiple myeloma. Following are the main treatment options available for multiple myeloma:

Close Monitoring
In some cases, multiple myeloma does not cause any serious symptoms, and the patient would be doing just fine; this condition is referred to as smouldering multiple myeloma. In such cases, the doctor may recommend ‘close monitoring’ wherein regular blood and urine tests are conducted to study the disease progression. The treatment is recommended only when the disease starts showing symptoms.
Chemotherapy
Chemotherapy is one of the standard treatment options available for multiple myeloma. This treatment approach involves the usage of powerful anticancer drugs, which, when injected, destroy the myeloma cells present throughout the body.
Targeted Therapy
Targeted therapy is a form of precision medicine that involves the usage of specific drugs that identify and attack myeloma cells only. Targeted therapy minimises damage to the healthy tissues and has a huge role in reducing the risk of treatment-related side effects in multiple myeloma patients.
Immunotherapy
In cancer patients, the disease-fighting ability of the body is compromised as cancer cells produce specific substances that keep them hidden from the immune cells. Immunotherapy works by triggering the patient’s immune system to launch an attack against the myeloma cells.
Bone Marrow Transplant
Bone marrow transplant involves the replacement of diseased bone marrow cells with healthy ones. Before the transplant, the patient is made to undergo high-dose chemotherapy, which helps in destroying the myeloma cells. Later, the healthy bone marrow, which is received from a donor, is transfused into the patient’s body for the production of healthy bone marrow cells.

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